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For example, in one experiment, male Sprague-Dawley rats were given either a low fat or a high fat diet, with the high fat diet containing 35% more fat than the low fat diet. The results of the study illustrate that the high fat diet rats had a higher adiposity index than the low fat diet rats. [42]
This breed of rat was first produced by the Sprague Dawley farms (later to become the Sprague Dawley Animal Company) in Madison, Wisconsin, in 1925. The name was originally hyphenated, although the brand styling today (Sprague Dawley, the trademark used by Inotiv) is not. The average litter size of the Sprague Dawley rat is 11.0. [29]
WAY-161503 has been reported to produce dose-dependent decreases in food intake in 24-hour fasted normal Sprague-Dawley rats, diet-induced obese mice, and obese Zucker rats with ED 50 values of 1.9, 6.8, and 0.73 mg/kg, respectively.
Sprague Dawley rat; W. Wistar rat; Z. ZDF rat; Zucker diabetic fatty rat; Zucker rat This page was last edited on 12 October 2015, at 22:02 (UTC). Text is available ...
Harlan UK Ltd. is the British arm of Harlan Sprague Dawley Inc. It has an annual turnover of £6.6 million, according to the British Union for the Abolition of Vivisection (BUAV). [6] The company supplies marmosets, beagles, cats, rabbits, guinea pigs, rats, mice, gerbils, and hamsters, as well as hybrid, mutant, and transgenic animals.
Sprague-Dawley rats have a lifespan of about two years and have a high risk of cancer over their lifespan (one study concluded that over eighty percent of males and over seventy percent of females developed cancer under normal conditions). [40] [41] [42] The Séralini experiment covered the normal lifespan of these rats. The longer an ...
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The company began offering rats in 1969, including Sprague Dawley, one of the most popular breeds of laboratory rats. That same year, Taconic became the first breeder to receive full accreditation from the American Association for the Accreditation of Laboratory Animals. [citation needed]