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Fibrodysplasia ossificans progressiva (/ ˌ f aɪ b r oʊ d ɪ ˈ s p l eɪ ʒ (i) ə ɒ ˈ s ɪ f ɪ k æ n z p r ə ˈ ɡ r ɛ s ɪ v ə /; [1] abbr. FOP), also called Münchmeyer disease or formerly myositis ossificans progressiva, is an extremely rare connective tissue disease in which fibrous connective tissue such as muscle, tendons, and ligaments turn into bone tissue (ossification).
The diaphysis (pl.: diaphyses) is the main or midsection (shaft) of a long bone. It is made up of cortical bone and usually contains bone marrow and adipose tissue (fat). It is a middle tubular part composed of compact bone which surrounds a central marrow cavity which contains red or yellow marrow. In diaphysis, primary ossification occurs.
The diaphysis is the midsection of the tibia, also known as the shaft or body. While the epiphyses are the two rounded extremities of the bone; an upper (also known as superior or proximal) closest to the thigh and a lower (also known as inferior or distal) closest to the foot. The tibia is most contracted in the lower third and the distal ...
Often, the body will try to create new bone around the area of necrosis. The resulting new bone is often called an involucrum. [13] On histologic examination, these areas of necrotic bone are the basis for distinguishing between acute osteomyelitis and chronic osteomyelitis. Osteomyelitis is an infective process that encompasses all of the bone ...
In a long bone it is a thin disc of hyaline cartilage that is positioned transversely between the epiphysis and metaphysis. In the long bones of humans, the epiphyseal plate disappears by twenty years of age. physis, "the growth part" metaphysis: The region of a long bone lying between the epiphysis and diaphysis.
The long bone category includes the femora, tibiae, and fibulae of the legs; the humeri, radii, and ulnae of the arms; metacarpals and metatarsals of the hands and feet, the phalanges of the fingers and toes, and the clavicles or collar bones. The long bones of the human leg comprise nearly half of adult height.
Various bones of the human skeletal system. The axial skeleton , comprising the spine, chest and head, contains 80 bones. The appendicular skeleton , comprising the arms and legs, including the shoulder and pelvic girdles, contains 126 bones, bringing the total for the entire skeleton to 206 bones.
In the human body at birth, approximately 300 bones are present. Many of these fuse together during development, leaving a total of 206 separate bones in the adult, not counting numerous small sesamoid bones. [3] [4] The largest bone in the body is the femur or thigh-bone, and the smallest is the stapes in the middle ear.