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Cushing's syndrome is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. [4] [9] [10] Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, [11] a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals ...
Striae, or "stretch marks", begin as reddish or purple lesions which can appear anywhere on the body, but are most likely to appear in places where larger amounts of fat are stored. The most common places are the abdomen (especially near the navel ), breasts, upper arms, underarms, back, thighs (both inner and outer), hips, and buttocks.
The symptoms of Cushing's disease are similar to those seen in other causes of Cushing's syndrome. [5] Patients with Cushing's disease usually present with one or more signs and symptoms secondary to the presence of excess cortisol or ACTH. [6] Although uncommon, some patients with Cushing's disease have large pituitary tumors (macroadenomas).
Cushing syndrome can be hard to diagnose. Here's what it is, as well as what causes it and how it's treated.
Stretch marks, also called striae, refer to areas of skin thinning, discoloration and wrinkling caused by periods of rapid body growth, like pregnancy or significant weight gain, says Li. They can ...
Signs of Cushing's syndrome include muscle weakness, easy bruising, weight gain, male-pattern hair growth , coloured stretch marks, and an excessively reddish complexion in the face. [38] Cushing's syndrome can cause androgen excess and hence the signs and symptoms of hyperandrogenism. [33]
In the alcoholic patient with pseudo-Cushing's, admission to hospital (and avoidance of alcohol) will result in normal midnight cortisol levels within five days, excluding Cushing's [6] Another cause for Cushing's syndrome is adrenocortical carcinoma. This is a rare form of cancer with an incidence of 1-2 per million people annually.
Moon face is often associated with Cushing's syndrome [5] [6] or steroid treatment (especially corticosteroids), which has led to it being known as Cushingoid facies. [7]Moon face is a type of corticosteroid-induced lipodystrophy along with "buffalo hump", which in one study occurred in 47% of the 820 patients.