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Venlafaxine, sold under the brand name Effexor among others, is an antidepressant medication of the serotonin–norepinephrine reuptake inhibitor (SNRI) class. [6] [9] It is used to treat major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. [9]
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
The recommended maximum daily dose of citalopram and escitalopram was reduced due to concerns with QT prolongation. [ 92 ] [ 93 ] [ 94 ] In overdose, fluoxetine has been reported to cause sinus tachycardia , myocardial infarction , junctional rhythms , and trigeminy .
The reuptake effects of venlafaxine are dose-dependent. At low doses (<150 mg/day), it acts only on serotonergic transmission. At moderate doses (>150 mg/day), it acts on serotonergic and noradrenergic systems, whereas at high doses (>300 mg/day), it also affects dopaminergic neurotransmission. [ 22 ]
Desvenlafaxine is a synthetic form of the isolated major active metabolite of venlafaxine, and is categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI). When most normal metabolizers take venlafaxine, approximately 70% of the dose is metabolized into desvenlafaxine, so the effects of the two drugs are expected to be very similar. [18]
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The dose should be increased after a minimum of 3 days up to approximately 1.2 mg/kg daily (target dose) as a single or two divided doses (in the morning and late afternoon). For children older than 6 years old, over 70 kg, acute treatment should be started with 40 mg/day orally and increased up to 80 mg/day after a minimum of 3 days.
Effexor and Effexor XR (venlafaxine) – an antidepressant of the SNRI class Elavil ( amitriptyline ) – a tricyclic antidepressant used as a first-line treatment for neuropathic pain Eurodin , Prosom ( estazolam ) – a benzodiazepine derivative with anxiolytic , anticonvulsant , hypnotic , sedative and skeletal muscle relaxant properties ...