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Since hemagglutinin is the major surface protein of the influenza A virus and is essential to the entry process, it is the primary target of neutralizing antibodies. [citation needed] These antibodies against flu have been found to act by two different mechanisms, mirroring the dual functions of hemagglutinin:
Many copies of a single viral protein or a number of different viral proteins make up the capsid, and each of these viral proteins are coded for by one gene from the viral genome. The structure of the capsid allows the virus to use a small number of viral genes to make a large capsid. [3]
Influenza A viruses are further classified, based on the viral surface proteins hemagglutinin (HA or H) and neuraminidase (NA or N). 18 HA subtypes (or serotypes) and 11 NA subtypes of influenza A virus have been isolated in nature. Among these, the HA subtype 1-16 and NA subtype 1-9 are found in wild waterfowl and shorebirds and the HA ...
This attachment is required for efficient transfer of flu virus genes into cells, a process that can be blocked by antibodies that bind to the hemagglutinin proteins. One genetic factor in distinguishing between human flu viruses and avian flu viruses is that avian influenza HA bind to alpha 2-3 sialic acid receptors while human influenza HA ...
Viral neuraminidase cleaves terminal sialic acid residues from glycan structures on the surface of the infected cell. This promotes the release of progeny viruses and the spread of the virus from the host cell to uninfected surrounding cells. Neuraminidase also cleaves sialic acid residues from viral proteins, preventing aggregation of viruses.
[25] rHA stimulate H1N1 surface protein and allow body to produce antibodies against it. rHA vaccine does not contain egg protein, or any other extraneous influenza virus proteins other than HA. This is an advantage for people who cannot tolerate egg or the other materials included in the conventional vaccine. [ 26 ]
There are two different influenza A dog flu viruses: one is an H3N8 virus and the other is an H3N2 virus. [88] The H3N8 strain has evolved from an equine influenza avian virus which has adapted to sustained transmission among dogs. The H3N2 strain is derived from an avian influenza which jumped to dogs in 2004 in either Korea or China. [88]
Figure 3 showed the structure of an influenza virus. The hemagglutinin (HA) surface proteins feature the influenza virus. The HA antigens of seasonal virus strains are the target for the influenza vaccines to trigger an immune response in the human body. During the manufacturing process, the virus’ gene is first obtained.