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Leptospirosis is treated in humans by the antibiotics penicillin and doxycycline. [7] [8] L. interrogans has many properties that ensure its optimal survival in specific conditions, including two periplasmic flagella for movement and mobility. These flagella enable L. interrogans to more easily access and infect both human and mammalian tissues ...
Leptospirosis is a blood infection caused by the bacterium Leptospira [8] that can infect humans, dogs, rodents and many other wild and domesticated animals. [8] Signs and symptoms can range from none to mild ( headaches , muscle pains , and fevers ) to severe ( bleeding in the lungs or meningitis ). [ 5 ]
Consensus statements differ from medical guidelines, another form of state-of-the-science public statements. According to the NIH, "Consensus statements synthesize new information, largely from recent or ongoing medical research, that has implications for reevaluation of routine medical practices. They do not give specific algorithms or ...
L. interrogans can also obtain iron from heme, which is bound to most of the iron in the human body. The HbpA hemin-binding protein, which may be involved in the uptake of hemin , has been identified on the surface of L. interrogans [ 35 ] Although other pathogenic species of Leptospira and L. biflexa lack HbpA, yet another hemin-binding ...
Pimobendan is indicated for the management of the signs of mild, moderate, or severe congestive heart failure in dogs due to clinical myxomatous mitral valve disease (MMVD) or dilated cardiomyopathy (DCM); [1] [7] and for use with concurrent therapy for congestive heart failure (e.g.,furosemide, etc.) as appropriate on a case-by-case basis. [1]
Lepto may be: the Modern Greek term for the Greek lepton unit of currency; an informal term for the leptospirosis disease, ... Cookie statement; Mobile view ...
This analysis can be restricted to only the participants who fulfill the protocol in terms of the eligibility, adherence to the intervention, and outcome assessment. This analysis is known as an "on-treatment" or "per protocol" analysis. A per-protocol analysis represents a "best-case scenario" to reveal the effect of the drug being studied.
Comparative medicine is a distinct discipline of experimental medicine that uses animal models of human and animal disease in translational and biomedical research. [1]: 2 [2] In other words, it relates and leverages biological similarities and differences among species to better understand the mechanism of human and animal disease.