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Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [10] used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. [11]
This is relevant as dopamine is thought to be involved in the pathophysiology of depression, and increased dopaminergic signaling by sertraline in addition to serotonin may have additional benefits against depression. [12] Tatsumi et al. (1997) found K i values of sertraline at the SERT, DAT, and NET of 0.29, 25, and 420 nM, respectively. [8]
Several meta-analytical studies have found increased levels of proinflammatory cytokines and chemokines in depressed patients. [190] This link has led scientists to investigate the effects of antidepressants on the immune system. SSRIs were originally invented with the goal of increasing levels of available serotonin in the extracellular spaces.
As for the Zoloft side effect in women, the most common intimacy side effect of sertraline and other SSRIs is a lower level of interest in intimacy and difficulty climaxing.
In children, SSRIs are considered as a second-line therapy in those with moderate-to-severe impairment, with close monitoring for psychiatric adverse effects. [53] Sertraline and fluoxetine are effective in treating OCD for children and adolescents. [42] [37] [43] Clomipramine, a TCA drug, is considered effective and useful for OCD. However, it ...
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS) and are implicated in many neurological processes, including motivational and incentive salience, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling.
[20] [55] For children and adolescents with moderate-to-severe depressive disorder, fluoxetine seems to be the best treatment (either with or without cognitive behavioural therapy) but more research is needed to be certain. [43] [44] [56] [55] Sertraline, escitalopram, duloxetine might also help in reducing symptoms. [55]
These include sertraline (the active ingredient in Zoloft), paroxetine (generic for Paxil) and sildenafil (Viagra). When used as prescribed, these medications might help you control your climax ...