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Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [10] used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. [11]
This is relevant as dopamine is thought to be involved in the pathophysiology of depression, and increased dopaminergic signaling by sertraline in addition to serotonin may have additional benefits against depression. [12] Tatsumi et al. (1997) found K i values of sertraline at the SERT, DAT, and NET of 0.29, 25, and 420 nM, respectively. [8]
Several meta-analytical studies have found increased levels of proinflammatory cytokines and chemokines in depressed patients. [190] This link has led scientists to investigate the effects of antidepressants on the immune system. SSRIs were originally invented with the goal of increasing levels of available serotonin in the extracellular spaces.
As for the Zoloft side effect in women, the most common intimacy side effect of sertraline and other SSRIs is a lower level of interest in intimacy and difficulty climaxing.
Sertraline. Sold under the brand ... Like other antidepressants, MAOIs work by boosting your brain’s level of certain neurotransmitters, such as serotonin, norepinephrine and dopamine. While ...
Typical DRIs are similar to substrate-type DRAs in their effects on brain dopamine levels and in their subjective and behavioral effects. [ 11 ] In terms of maximal brain dopamine elevations, typical DRIs or DAT "inverse agonists" can increase levels by 500 to 1,500%, substrate-type DRAs by more than 1,000% (as high as 5,000% or more), and ...
Researchers believe this may affect neurotransmitters (chemicals that communicate throughout the brain and body), including some involved in intimate excitement and function.
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS) and are implicated in many neurological processes, including motivational and incentive salience, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling.