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Some authors have broadened the definition of the Michael addition to essentially refer to any 1,4-addition reaction of α,β-unsaturated carbonyl compounds. Others, however, insist that such a usage is an abuse of terminology, and limit the Michael addition to the formation of carbon–carbon bonds through the addition of carbon nucleophiles.
Arthur Michael is remembered today primarily for the Michael reaction, also called the Michael addition. As originally defined by Michael, the reaction involves the combination of an enolate ion of a ketone or aldehyde to an α,β-unsaturated carbonyl compound at the β carbon. [6] Michael was also well known in his day for incorporating ...
Multiple Michael/aldol reaction for construction of macrolide structures. Multiple Michael/aldol reaction (or domino Michael/aldol reaction) is a consecutive series of reactions composed of either Michael addition reactions or aldol reactions. More than two steps of reaction are usually involved.
Generalised Tandem Michael-aldol reaction. Robinson annulation is one notable example of a wider class of chemical transformations termed Tandem Michael-aldol reactions, that sequentially combine Michael addition and aldol reaction into a single reaction. As is the case with Robinson annulation, Michael addition usually happens first to tether ...
Thiol-ene reactions are known to proceed through a Michael addition pathway. These reactions are catalyzed by either a base or a nucleophile, resulting in a similar anti-Markovnikov addition product as the thiol-ene radical addition. [6]
Camphorsultam also acts as a chiral auxiliary in Michael addition. Lithium base promoted stereoselective Michael addition of thiols to N-mcthacryloylcamphorsultam produced the corresponding addition products in high diastereoselectivity. [24] Camphorsultam was used as a chiral auxiliary in Michael addition.
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Pages in category "Addition reactions" The following 74 pages are in this category, out of 74 total. ... Michael addition reaction; Milas hydroxylation; Mukaiyama ...