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Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ubiquitously.It was discovered in 1975 [1] by Gideon Goldstein and further characterized throughout the late 1970s and 1980s. [2]
At the start of the ubiquitination cascade, the E1 enzyme (Figure 2) binds ATP-Mg 2+ and ubiquitin and catalyses ubiquitin C-terminal acyl adenylation. [4] In the next step a catalytic cysteine (Figure 3) on the E1 enzyme attacks the ubiquitin-AMP complex through acyl substitution, simultaneously creating a thioester bond and an AMP leaving group. [2]
Ubiquiti Inc. (formerly Ubiquiti Networks, Inc.) [3] is an American technology company founded in San Jose, California, in 2003. [ 1 ] [ 4 ] Now based in New York City , [ 5 ] Ubiquiti manufactures and sells wireless data communication and wired products for enterprises and homes under multiple brand names.
A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin from the E2 to the protein substrate.
Mark Weiser coined the phrase "ubiquitous computing" around 1988, during his tenure as Chief Technologist of the Xerox Palo Alto Research Center (PARC).Both alone and with PARC Director and Chief Scientist John Seely Brown, Weiser wrote some of the earliest papers on the subject, largely defining it and sketching out its major concerns.
The history of biology traces the study of the living world from ancient to modern times. Although the concept of biology as a single coherent field arose in the 19th century, the biological sciences emerged from traditions of medicine and natural history reaching back to Ayurveda, ancient Egyptian medicine and the works of Aristotle, Theophrastus and Galen in the ancient Greco-Roman world.
A tree of life, like this one from Charles Darwin's notebooks c. July 1837, implies a single common ancestor at its root (labelled "1").. A phylogenetic tree directly portrays the idea of evolution by descent from a single ancestor. [3]
Ubiquity may refer to: . Ubiquity (software), a simple graphical installer made for the Ubuntu operating system Ubiquity (Firefox), an experimental extension for the Firefox browser