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Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA(A) subunits. This gene encodes the gamma 2 subunit of GABA(A) receptor.
It was found that the chemically synthesized GABA reduces blood pressure in experimental animals [2] [3] and humans. [4] Further research demonstrated that GABA tea was also able to reduce the blood pressure in experimental animals and humans. [5] [6] [7] [full citation needed] GABA tea production was also widely adopted by Taiwanese tea makers.
Gamma-aminobutyric acid receptor subunit alpha-2 is a protein in humans that is encoded by the GABRA2 gene. [ 4 ] GABRA2 is an alpha subunit that is part of GABA-A receptors, which are ligand-gated chloride channels and are activated by the major inhibitory neurotransmitter in the mammalian brain, GABA .
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Each binds GABA with varying affinities with BGT1 having the lowest affinity and GAT3 the highest. GAT2 (SLC6A13) is predominantly expressed in hepatocytes in the liver, but is also found in proximal tubules in the kidney as well as in the leptomeninges and in some blood vessels in the brain. [2]
[9] [10] Because GABA-T degrades GABA, the inhibition of this enzyme has been the target of many medical studies. [9] The goal of these studies is to find a way to inhibit GABA-T activity, which would reduce the rate that GABA and 2-oxoglutarate are converted to semialdehyde and L-glutamate, thus raising GABA concentration in the brain.
How to Meal-Prep Your Week of Meals: Make Apple-Pomegranate Overnight Oats to have for breakfast on days 2 through 5.. Day 1 Breakfast (337 calories) 1 serving Chocolate-Cherry Protein Shake. A.M ...
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