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The Notch signaling pathway is important for cell-cell communication, which involves gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. Notch signaling also has a role in the following processes: neuronal function and development [44] [45] [46] [47]
This is an example of a locally acting (negative feedback) mechanism. An example of upregulation is the response of liver cells exposed to such xenobiotic molecules as dioxin . In this situation, the cells increase their production of cytochrome P450 enzymes , which in turn increases degradation of these dioxin molecules.
Notch proteins are a family of type 1 transmembrane proteins that form a core component of the Notch signaling pathway, which is highly conserved in animals. The Notch extracellular domain mediates interactions with DSL family ligands , allowing it to participate in juxtacrine signaling .
The Notch signaling pathway is a highly conserved pathway that functions to establish and regulate cell fate decisions in many organ systems. Once the JAG1-NOTCH (receptor-ligand) interactions take place, a cascade of proteolytic cleavages is triggered resulting in activation of the transcription for downstream target genes.
The notch/STAT3-Ser/Hes3 signaling axis is a recently identified signal transduction branch of the notch [1] signaling pathway, originally shown to regulate the number of neural stem cells in culture and in the living adult brain. [2] [3] Pharmacological activation of this pathway opposed the progression of neurodegenerative disease in rodent ...
Regulation of gene expression by a hormone receptor Diagram showing at which stages in the DNA-mRNA-protein pathway expression can be controlled. Regulation of gene expression, or gene regulation, [1] includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA).
Numb acts as an oncogene suppressor, inhibiting tumor cell proliferation through suppression of Notch signaling. Increased Notch signaling is observed in tumors where Numb activity has been lost and retrovirally mediated transient overexpression of Numb protein in these tumors restored basal levels of Notch signaling and significantly reduced ...
The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch ...