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Most infections with C. neoformans occur in the lungs, as the fungus enters its host through the respiratory route. [14] Because it is normally a harmless soil fungus, C. neoformans must first adapt to its new environment inside the human body, making several virulent transformations, including the formation of a polysaccharide capsule.
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C. gattii infections were initially thought to be restricted to tropical [1] [12] and subtropical regions. [12] C. gattii is the predominant cause of cryptococcosis in sub-Saharan Africa. [13] The highest incidences of C. gattii infections occur in Papua New Guinea and Northern Australia.
The teleomorph was first described in 1975 by K.J. Kwon-Chung, who obtained cultures of the type species, Filobasidiella neoformans, by crossing strains of the yeast Cryptococcus neoformans. She was able to observe basidia similar to those of the genus Filobasidium , hence the name Filobasidiella for the new genus. [ 3 ]
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However, there are examples of animal and human parasites where the species are dimorphic but it is the yeast-like state that is infectious. [18] The genus Filobasidiella forms basidia on hyphae but the main infectious stage is more commonly known by the anamorphic yeast name Cryptococcus, e.g. Cryptococcus neoformans [19] and Cryptococcus ...
Candidiasis is a fungal infection due to any species of the genus Candida (a yeast). [4] When it affects the mouth, in some countries it is commonly called thrush. [3] Signs and symptoms include white patches on the tongue or other areas of the mouth and throat. [3]