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Although topiramate does inhibit high-voltage-activated calcium channels, its relevance to clinical activity is uncertain. Effects on specific GABA-A receptor isoforms could also contribute to the antiseizure activity of the drug. Topiramate selectively inhibits cytosolic (type II) and membrane-associated (type IV) forms of carbonic anhydrase.
The United States Drug Enforcement Administration (DEA) maintains lists regarding the classification of illicit drugs (see DEA Schedules).It also maintains List I of chemicals and List II of chemicals, which contain chemicals that are used to manufacture the controlled substances/illicit drugs.
In the US, the drug label contains warnings for increased heart rate, suicidal behavior and ideation, glaucoma, mood and sleep disorders, creatinine elevation, and metabolic acidosis. Some of these warnings are based on historical observations in epilepsy patients taking topiramate.
The Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) study showed that most blood concentrations in breastfed infants of mothers taking carbamazepine, oxcarbazepine, valproate, levetiracetam, and topiramate were quite low, especially in relationship to the mother's level and what the fetal level would have been ...
This is the list of extremely hazardous substances defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. § 11002). The list can be found as an appendix to 40 CFR 355. [1] Updates as of 2006 can be seen on the Federal Register, 71 FR 47121 (August 16, 2006). [2]
Topamax – an anticonvulsant used to treat epilepsy and migraine headaches; Trileptal (oxcarbazepine) – an anticonvulsant used as a mood stabilizer; Trintellix (vortioxetine) – an antidepressant of the serotonin modulator and stimulator class; Tegretol (carbamazepine) – an anticonvulsant used as a mood stabilizer
[8] [10] The drug robustly and dose-dependently elevates brain norepinephrine and dopamine levels in animals. [8] Phentermine is more potent in its effects on norepinephrine than on dopamine and the drug shows only weak effects on serotonin .
JNJ-26489112 is an anticonvulsant drug being developed by Johnson & Johnson for the treatment of epilepsy. [ 1 ] [ 2 ] [ 3 ] JNJ-26489112 was designed as a successor to topiramate . [ 4 ] It is expected to have fewer side effects than topiramate because it lacks activity against carbonic anhydrase .