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Roseola, also known as sixth disease, is an infectious disease caused by certain types of human herpes viruses. [2] Most infections occur before the age of three. [ 1 ] Symptoms vary from absent to the classic presentation of a fever of rapid onset followed by a rash.
Primary infection with this virus is the cause of the common childhood illness exanthema subitum (also known as roseola infantum or sixth disease). Additionally, reactivation is common in transplant recipients, which can cause several clinical manifestations such as encephalitis , bone marrow suppression, and pneumonitis .
[19] [20] HHV-6B is commonly detected in children with roseola infantum, as it is the etiologic agent for this condition. Within these two viruses is a sequence homology of 95%. [21] In 2012, HHV-6A and HHV-6B were officially recognized as distinct species. [1]
Roseola infantum; References This page was last edited on 9 June 2024, at 04:11 (UTC). Text is available under the Creative Commons Attribution ...
The acquisition of HHV-6 in infancy is often symptomatic, resulting in childhood fever, diarrhea, and exanthem subitum rash (commonly known as roseola). Although rare, this initial infection can also cause febrile seizures , encephalitis or intractable seizures.
Schematic drawing of a Herpesviridae virion. All members of the Herpesviridae share a common structure; a relatively large, monopartite, double-stranded, linear DNA genome encoding 100–200 genes encased within an icosahedral protein cage (with T=16 symmetry) called the capsid, which is itself wrapped in a protein layer called the tegument containing both viral proteins and viral mRNAs and a ...
Mammals serve as natural hosts. There are 26 species in this subfamily, divided among 5 genera. Diseases associated with this subfamily include: human cytomegalovirus (HHV-5): congenital CMV infection; HHV-6: 'sixth disease' (also known as roseola infantum or exanthem subitum); HHV-7: symptoms analogous to the 'sixth disease'. [1] [2]
Roseola infantum (exanthem subitum) "sixth disease" HHV-6 and HHV-7: Rapid onset of erythematous, blanching macules and papules surrounded by white halos on the trunk after 3-5 days of high fever. The rash spreads to the neck and body extremities and lasts 1-2 days.