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Clotiazepam is metabolised to hydroxy-clotiazepam and desmethyl-clotiazepam. After oral ingestion of a single 5 mg dose of clotiazepam by three healthy volunteers the drug was rapidly absorbed. [15] The elimination half-life of the drug and its metabolites range from 6.5 hours to 18 hours. Clotiazepam is 99 percent bound to plasma protein. [15]
Rilmazafone is not a benzodiazepine, since there is no benzene ring fused with a diazepine ring in the compound; in fact, the parent drug has no diazepine ring. It is therefore not classified as a benzodiazepine in several countries, including the United States, where it is not designated a controlled substance .
Some terms that are similar or equivalent in some contexts are slide, sweep bend, smear, rip (for a loud, violent glissando to the beginning of a note), [1] lip (in jazz terminology, when executed by changing one's embouchure on a wind instrument), [2] plop, or falling hail (a glissando on a harp using the back of the fingernails). [3]
It is among the most rapidly absorbed and quickest acting oral benzodiazepines, and hypnotic effects are typically felt within 15–30 minutes after oral ingestion. The blood level decline of the parent drug was biphasic with the short half-life ranging from 0.5–0.7 hours and the terminal half-life from 8 to 26.5 hours (mean 17.25 hours).
Suggested notation of music for flexatone, using roll symbols for the tremolo and approximate pitch [3] Rhythmic pattern easily playable on the flexatone [4]. The flexatone or fleximetal is a modern percussion instrument (an indirectly struck idiophone) consisting of a small flexible metal sheet suspended in a wire frame ending in a handle. [5]
Bromazepam is commonly involved in drug overdoses. [65] A severe bromazepam benzodiazepine overdose may result in an alpha pattern coma type. [66] The toxicity of bromazepam in overdosage increases when combined with other CNS depressant drugs such as alcohol or sedative hypnotic drugs. [67]
Lurasidone [(3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl) piperazin-1-ylmethyl]-cyclohexylmethyl}-hexahydro-4,7-methano-2Hisoindole-1,3-dione hydrochloride]] [71] is an azapirone derivative [72] and acts as an antagonist of the dopamine D 2 and D 3 receptors, [73] and the serotonin 5-HT 2A and 5-HT 7 receptors, and the α 2C ...
All compounds submitted by the chemical staff for central nervous activity were screened. It was this battery of tests that picked out RO 5-0690 (Librium, chlordiazepoxide) as being similar but more potent than meprobamate." [34] Three years later chlordiazepoxide was marketed as a therapeutic benzodiazepine medication under the brand name Librium.