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The most common side effects reported with naltrexone are gastrointestinal complaints such as diarrhea and abdominal cramping. [3] These adverse effects are analogous to the symptoms of opioid withdrawal, as the μ-opioid receptor blockade will increase gastrointestinal motility. The side effects of naltrexone by incidence are as follows: [3]
Disulfiram is a medication used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme aldehyde dehydrogenase (specifically the ALDH2 enzyme [3]), causing many of the effects of a hangover to be felt immediately following alcohol consumption.
Unlike acetaldehyde dehydrogenase inhibitors and other disulfiram-like drugs, alcohol dehydrogenase inhibitors such as fomepizole (brand name Antizol) inhibit the metabolism of alcohol into acetaldehyde, thereby increasing and extending the effects of alcohol and reducing its toxicity. [4]
“It’s a growing problem. Alcohol is a very simple molecule with very diverse effects on physiology,” explains White. “There aren’t many things the body does that alcohol doesn’t impact.”
This study rated alcohol the most harmful drug overall, and the only drug more harmful to others than to the users themselves. [4] Alcohol withdrawal syndrome (AWS) is a set of symptoms that can occur following a reduction in or cessation of alcohol use after a period of excessive use. [1]
The researchers concluded that GLP-1 receptor agonist medications—especially semaglutide—"offer promise as a novel treatment to reduce alcohol consumption and to prevent development of alcohol ...
Pharmacological treatments for alcohol addiction include drugs like naltrexone (opioid antagonist), disulfiram, acamprosate, and topiramate. [ 28 ] [ 29 ] Rather than substituting for alcohol, these drugs are intended to affect the desire to drink, either by directly reducing cravings as with acamprosate and topiramate, or by producing ...
It’s easier than ever for doctors to prescribe a key medicine for opioid addiction since the U.S. government lifted an obstacle last year. Researchers analyzed prescriptions filled by U.S ...
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