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Genital herpes is a herpes infection of the genitals caused by the herpes simplex virus (HSV). [1] Most people either have no or mild symptoms and thus do not know they are infected. [ 1 ] When symptoms do occur, they typically include small blisters that break open to form painful ulcers . [ 1 ]
Herpes simplex, often known simply as herpes, is a viral infection caused by the herpes simplex virus. [5] Herpes infections are categorized by the area of the body that is infected. The two major types of herpes are oral herpes and genital herpes, though other forms also exist. Oral herpes involves the face or mouth.
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. [1] [2] Both HSV-1 and HSV-2 are very common and contagious. They can be spread when an infected person begins shedding the virus.
Autoinoculation (self-infection) can occur through self-contact, leading to infection at multiple sites on the body. [5] Herpes gladiatorum symptoms may last up to a few weeks, and if they occur during the first outbreak, they can be more pronounced. In recurrences of the ailment, symptoms are milder, even if lesions still tend to occur.
Aciclovir acts by inhibiting viral DNA replication and is used for the treatment of herpes simplex virus (HSV) and varicella zoster virus infections, including: [3] [15] [16] Genital herpes simplex (treatment and prevention) Neonatal herpes simplex; Herpes simplex labialis ; Shingles; Acute chickenpox in immunocompromised patients
Herpes simplex virus 2 infects humans, most often as genital herpes. In the United States more than one in six people have the virus. [4] It is primarily a sexually transmitted infection. [5] Herpes simplex virus 2 tends to reside in the sacral ganglia. Herpes simplex virus 2 is periodically shed in the human genital tract, most often ...
Pritelivir (development codes AIC316 or BAY 57-1293) is a direct-acting antiviral drug in development for the treatment of herpes simplex virus infections (HSV). This is particularly important in immune compromised patients. It is currently in Phase III clinical development by the German biopharmaceutical company AiCuris Anti-infective Cures AG.
In addition to demonstrating efficacy against HIV, CAPRISA 004 found evidence that tenofovir gel also prevents the transmission of herpes simplex virus type 2 (HSV-2). HSV-2 is a lifelong, incurable infection which can make those infected with the virus two-to-three times more likely to acquire HIV.
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