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Insulin lispro, sold under the brand name Humalog among others, is a modified type of medical insulin used to treat type 1 and type 2 diabetes. [5] It is delivered subcutaneously either by injection or from an insulin pump. [5] [6] Onset of effects typically occurs within 30 minutes and lasts about 5 hours. [5]
Onset of effects is typically in 90 minutes and they last for 24 hours. [3] Versions are available that come premixed with a short-acting insulin, such as regular insulin. [2] The common side effect is low blood sugar. [3] Other side effects may include pain or skin changes at the sites of injection, low blood potassium, and allergic reactions. [3]
The insulin aspart protamine portion is a crystalline form of insulin aspart, which delays the action of the insulin, giving it a prolonged absorption profile after injection. [14] The combination of the fast-acting form and the long-acting form allows the patient to receive fewer injections over the course of the day. [27]
People who wish to reduce repeated skin puncture of insulin injections often use an injection port in conjunction with syringes. [ 51 ] The use of subcutaneous injections of insulin is designed to mimic the natural physiological cycle of insulin secretion, while taking into account the various properties of the formulations used such as half ...
It is administered once daily and has a duration of action that lasts up to 40 hours (compared to 18 to 26 hours provided by other marketed long-acting insulins such as insulin glargine and insulin detemir). [6] [7] The change involves attachment of a hexadecanedioic acid tail to the B29 lysine's "tail" nitrogen. This allows the molecule to ...
Insulin pump in use Diabetic child wearing a state-of-the-art insulin pump (referred to as a "patch pump"). His waterproof device needs no one infusion set. An insulin pump is a medical device used for the administration of insulin in the treatment of diabetes mellitus, also known as continuous subcutaneous insulin therapy.
A fast-reacting drug means insulin injections do not have to precede mealtimes by hours, which in turn gives people with diabetes more flexibility in their daily schedules. [47] Insulin can aggregate and form fibrillar interdigitated beta-sheets. This can cause injection amyloidosis, and prevents the storage of insulin for long periods. [48]
Insulin degludec is an ultra-long acting insulin that, unlike insulin glargine, is active at a physiologic pH.The addition of hexadecanedioic acid via an amide linkage to lysine at the B29 position allows for the formation of multi-hexamers in subcutaneous tissues. [16]