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Benfotiamine has been studied in laboratory models of diabetic retinopathy, neuropathy, and nephropathy. [10] A 2021 review of its use for diabetic polyneuropathy described two clinical trials which showed improvements in neuropathic pain and neuropathic symptoms scores, the latter of which showed a dose-response effect. [4]
According to the Anxiety and Depression Association of America (ADAA), 6.8 million adults have GAD. Other anxiety disorders include obsessive-compulsive disorder, panic disorder, post-traumatic ...
Adverse effects found in clinical trials are usually limited to headache and gastrointestinal discomfort when high doses are used. While daily use can result in tolerance and paradoxical drowsiness, increasing the dose is strongly discouraged and side effects can include diarrhea, bladder infections, bronchitis, back pain, abdominal pain, insomnia, constipation, gastroenteritis, headache ...
Side effects of etifoxine include slight drowsiness and headache. [2] [9] Rarely, etifoxine can cause benign skin eruptions or rashes and allergic reactions such as hives and angioedema. [2] [8] [1] Etifoxine shows less adverse effects of anterograde amnesia, sedation, impaired psychomotor performance, and withdrawal syndromes than those of ...
Selank has an advantage over traditional anxiety treatments, such as benzodiazepines, as it has no sedating or negative cognitive side effects and no associated addiction or withdrawal problems. [citation needed] Selank is closely related to another nootropic drug, Semax, also developed by the Institute of Molecular Genetics in Russia. This ...
Effects typically begin within five minutes. [4] Doses are then increased to effect. [4] Common side effects include worsening kidney function, an irregular heartbeat, chest pain, vomiting, headache, or anxiety. [4] If it enters into the soft tissue around the vein local tissue death may occur. [4]
Side effects of guanfacine are dose-dependent. [29]Very common (>10% incidence) adverse effects include sleepiness, tiredness, headache, and stomach ache. [30]Common (1–10% incidence) adverse effects include decreased appetite, nausea, dry mouth, urinary incontinence, and rashes.
Tianeptine has antidepressant and anxiolytic effects [13] with a relative lack of sedative, anticholinergic, and cardiovascular side effects. [ 10 ] [ 14 ] It has been found to act as an atypical agonist of the μ-opioid receptor with clinically negligible effects on the δ- and κ-opioid receptors .
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