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Long-term use (more than six weeks) may lead to accumulation and toxicity. [8] High daily intake over a period of months can possibly cause severe fatigue, weakness and neurological symptoms that reverse with discontinuation. [9] Some of the risks of salicylism can apply to the use of bismuth subsalicylate. [10] [11] [12]
Table 2 Long-term use of antacids containing aluminum may increase the risk of developing osteoporosis. [9] In vitro studies have found a potential for acid rebound to occur due to antacid overuse, however the significance of this finding has been called into question. [10] [11]
Infrequent adverse effects include rash, itch, flatulence, constipation, anxiety, and depression. Also infrequently, PPI use may be associated with occurrence of myopathies, including the serious reaction rhabdomyolysis. [31] Long-term use of PPIs requires assessment of the balance of the benefits and risks of the therapy.
Antacids, H2 blockers (which work to reduce stomach acid), and proton pump inhibitors (PPIs) may provide relief from acid reflux symptoms. However, always consult a healthcare professional before ...
New research suggests that people who take antacids may be at greater risk for migraine attacks and severe headaches.
Antacids would increase the pH environment in the stomach and cause premature release of enteric coated drugs, which are designed to be protected from an acidic environment in stomach. [21] For example, proton-pump inhibitors (PPIs) are enteric coated to protect them from decomposition under an acidic environment. [ 22 ]
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