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This is a list of local anesthetic agents. Not all of these drugs are still used in clinical practice and in research. ... Novocain, borocaine (procaine borate ...
Procaine is a local anesthetic drug of the amino ester group. It is most commonly used in dental procedures to numb the area around a tooth [1] and is also used to reduce the pain of intramuscular injection of penicillin. Owing to the ubiquity of the trade name Novocain or Novocaine, in some regions, procaine is referred to generically as ...
Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom). A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, [1] providing local anesthesia, as opposed to a general anesthetic, which eliminates all sensation in the entire body and causes ...
It is a form of penicillin which is a salt of benzylpenicillin and the local anaesthetic agent procaine. [9] The salt has weak solubility, and is prepared as a suspension. Upon injection it forms a deposit within tissue (a "depot'), and the salt slowly dissolves into interstitial fluid - dissociating the two molecules into their bioactive forms over an extended pe
Structurally, amino esters consist of three molecular components: a lipophilic part (ester); an intermediate aliphatic chain; a hydrophilic part (amine); The chemical linkage between the lipophilic part and the intermediate chain can be of the amide-type or the ester-type, and is the general basis for the current classification of local anesthetics.
Diethylethanolamine reacts with 4-aminobenzoic acid to make procaine. DEAE is a precursor for DEAE-cellulose resin, which is commonly used in ion exchange chromatography. it can decrease the surface tension of water when the temperature is increased. [3] Solutions of DEAE absorb carbon dioxide (CO 2).
A topical anesthetic is a local anesthetic that is used to numb the surface of a body part. They can be used to numb any area of the skin as well as the front of the eyeball , the inside of the nose , ear or throat , the anus and the genital area . [ 1 ]
The Meyer-Overton correlation for anaesthetics. A nonspecific mechanism of general anaesthetic action was first proposed by Emil Harless and Ernst von Bibra in 1847. [9] They suggested that general anaesthetics may act by dissolving in the fatty fraction of brain cells and removing fatty constituents from them, thus changing activity of brain cells and inducing anaesthesia.