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The lipomas are well-encapsulated, slow-growing, benign fatty tumors. The distribution is defined as being focused in the trunk of the body and extremities. [2] Familial Multiple Lipomatosis can be identified when multiple lipomas occur in multiple family members that span different generations. [2] Some people may have hundreds of lipomas ...
Other entities which are accompanied by multiple lipomas include Proteus syndrome, Cowden syndrome and related disorders due to PTEN gene mutations, benign symmetric lipomatosis (Madelung disease), Dercum's Disease, familial lipodystrophy, hibernomas, epidural steroid injections with epidural lipomatosis, [6] and familial angiolipomatosis.
The tendency to develop a lipoma is not necessarily hereditary, although hereditary conditions such as familial multiple lipomatosis might include lipoma development. [ 15 ] [ 16 ] Genetic studies in mice have shown a correlation between the HMG I-C gene (previously identified as a gene related to obesity) and lipoma development.
Benign symmetric lipomatosis, also known as Madelung's disease, is an adult-onset skin condition characterized by extensive symmetric fat deposits in the head, neck, and shoulder girdle area. [1]
For example, a lipoma is a common benign tumor of fat cells , and a chondroma is a benign tumor of cartilage-forming cells (chondrocytes). Adenomas are benign tumors of gland-forming cells, and are usually specified further by their cell or organ of origin, as in hepatic adenoma (a benign tumor of hepatocytes , or liver cells).
The tendency to develop a lipoma is not necessarily hereditary, although it is in a syndrome like familial multiple lipomatosis (where more than one lipoma develops over time.)[11] Hereditary lipomatosis is an autosomal dominant disorder and is a rare condition.[12]
Familial cold urticaria (familial cold autoinflammatory syndrome) Familial Mediterranean fever; Hyper-IgD syndrome [nb 7] Majeed syndrome; Muckle–Wells syndrome; TNF receptor associated periodic syndrome (familial Hibernian fever, TRAPS, tumor necrosis factor receptor associated periodic syndrome)
Angiolipoma is a subcutaneous nodule with vascular structure, having all other features of a typical lipoma. They are commonly painful. [1]: 624 [2] Angiolipomas manifest as multiple painful subcutaneous nodules commonly on the upper limbs. The can occur sporadically, with a family history or after trauma.