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The HFE gene provides instructions for producing a protein that is located on the surface of cells, primarily liver and intestinal cells. The HFE protein is also found on some immune system cells. The HFE protein interacts with other proteins on the cell surface to detect the amount of iron in the body.
However, HFE is only part of the story, since many patients with mutated HFE do not manifest clinical iron overload, and some patients with iron overload have a normal HFE genotype. A possible explanation is the fact that HFE normally plays a role in the production of hepcidin in the liver, a function that is impaired in HFE mutations.
It is possible to delete part or all of a gene of interest in mice (or other experimental animals) as a means of studying function of the gene and its protein. Such mice are called “knockouts” with respect to the deleted gene. Hfe is the mouse equivalent of the human hemochromatosis gene HFE. The protein encoded by HFE is Hfe.
HFE. The HFE H63D is a single-nucleotide polymorphism in the HFE gene (c.187C>G, rs1799945), which results in the substitution of a histidine for an aspartic acid at amino acid position 63 of the HFE protein (p.His63Asp). HFE participates in the regulation of iron absorption. [1] [2] [3]
The company was founded in 1997 and is headquartered in Brussels, Belgium with sales offices and Service Operation Centers worldwide, including Dubai, Singapore, Bern, San Francisco and New York. BICS provides services across more than 200 countries, carries around 50% of the world's data roaming traffic and partners with more than 500 mobile ...
GBAS Approach Service Type GBAS Ground based augmentation system GCAS Ground collision avoidance system GBST ground-based, software tool Airfield operations GCA Ground-controlled approach: Airfield operations GCU generator control unit GDOP Geometric dilution of precision GEA Ground effect area: GGS Global positioning system ground station GHz
This is a very widely deployed switching system found in Italy, Germany, Belgium, Australia and many other countries around the world. There are a large number of versions of this type of switch ranging from local, to transit to international gateway to mobile switching centers. The line was converted with the E10 family of exchanges. OmniPCX ...
Product code may also refer to: Universal Product Code, common barcode used to identify packaged products; Electronic Product Code, an RFID code mainly applied as a packaging code for packaged products; Motion Picture Production Code (production code for short) Product key, a number used to verify the authenticity of a software as a license code