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Both GAD 67 and GAD 65 are also regulated post-translationally by pyridoxal 5’-phosphate (PLP); GAD is activated when bound to PLP and inactive when not bound to PLP. [23] Majority of GAD 67 is bound to PLP at any given time, whereas GAD 65 binds PLP when GABA is needed for neurotransmission. [ 23 ]
Gaëtan Dugas (French: [ɡaetɑ̃ dyɡa]; February 20, 1953 – March 30, 1984) was a Canadian flight attendant whose role in the early years of the AIDS epidemic attracted considerable attention. Initially identified as a central figure labeled " Patient Zero ", Dugas faced allegations of being a primary source of HIV transmission to the ...
In another example, male mice were socially isolated as a form of stress. Offspring of these mice had increased anxiety in response to stressful conditions, increased stress hormone levels, dysregulation of the HPA axis which plays a key role in stress response, and several other characteristics that indicated increased sensitivity to stress.
Pharmaceutical formulation, in pharmaceutics, is the process in which different chemical substances, including the active drug, are combined to produce a final medicinal product. The word formulation is often used in a way that includes dosage form .
Drifting smoke particles indicate the movement of the surrounding gas.. Gas is one of the four fundamental states of matter.The others are solid, liquid, and plasma. [1] A pure gas may be made up of individual atoms (e.g. a noble gas like neon), elemental molecules made from one type of atom (e.g. oxygen), or compound molecules made from a variety of atoms (e.g. carbon dioxide).
A clinical formulation, also known as case formulation and problem formulation, is a theoretically-based explanation or conceptualisation of the information obtained from a clinical assessment. It offers a hypothesis about the cause and nature of the presenting problems and is considered an adjunct or alternative approach to the more ...
Insulin glargine, for example, is designed to precipitate after injection so it can be slowly absorbed by the body over a longer period than regular insulin would be. [13] Depot injections of insulins have been studied to better replicate the body's natural basal rate of insulin production, and which can be activated by light to control the ...
For example, if someone fears public speaking, the person may be asked to give a speech to a small group of people. virtual reality, in which technology is used to simulate in vivo exposure. imaginal, where patients are asked to imagine a situation that they are afraid of. This procedure is helpful for people who need to confront feared ...