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“Most acne treatments—like cleansers, spot treatments, and lotions—contain salicylic acid in the 0.5 to two percent range,” she says. “One to two percent is common for spot treatments ...
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Historically, lotions also had an advantage in that they may be spread thinly compared to a cream or ointment and may economically cover a large area of skin, but product research has steadily eroded this distinction. Non-comedogenic lotions are recommended for use on acne prone skin. [4]
The topical cream formulation has a higher content of oily substance than gel, but a lower content of oily ingredient than ointment. Therefore, the viscosity of topical cream formulation lies between gel and ointment. [1] The pharmacological effect of the topical cream formulation is confined to the skin surface or within the skin. [3]
Benzoyl peroxide was first proposed as a treatment in 1958 and remains a staple of acne treatment. [209] The introduction of oral tetracycline antibiotics (such as minocycline) modified acne treatment in the 1950s. These reinforced the idea amongst dermatologists that bacterial growth on the skin plays an important role in causing acne. [206]
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