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As Izzie Stevens (Katherine Heigl) comes to terms with her Stage 4 metastatic melanoma diagnosis, she begins to refuse treatment, insisting she doesn’t want to fight the brain tumor. Cristina Yang ( Sandra Oh ), desperate to help Izzie, tries to convince her to reconsider, but her focus on Izzie starts affecting her own surgical performance.
Meanwhile, George O'Malley (T. R. Knight) feels betrayed by Izzie Stevens (Katherine Heigl) for not informing him about her cancer diagnosis. In an effort to distract himself, he requests to work with Callie for the day, avoiding his emotional turmoil.
Izzie's presence continues to influence Alex throughout later seasons, particularly in his relationship with Jo Wilson (Camilla Luddington). In the Season 12, "I Choose You", Jo discovers an invoice from the fertility clinic that stored the embryos created when Izzie had cancer, sparking questions about whether Alex might have children with ...
Izzie Stevens (Katherine Heigl) returns to work full-time, despite still recovering from her cancer treatment, wearing an auburn wig to conceal her hair loss. Lexie Grey ( Chyler Leigh ) is tasked with transferring blood to the OR for a trauma patient but slips while rushing through the hospital.
The episode opens with a voice-over narration from Meredith Grey (Ellen Pompeo) about the rapid passing of time.. Izzie Stevens (Katherine Heigl) has a mental collapse after the loss of her fiancé, Denny Duquette (Jeffrey Dean Morgan), as she refuses to deal with the repercussions of her decision to leave the internship program, by lying on the bathroom floor.
In an attempt to reason with Meredith, Derek makes her an offer: if she lets him report Webber, he will use his influence to get Izzie reinstated at the hospital once he takes over as Chief. Stevens returns to the hospital for a positron emission tomography (PET) scan, and it is revealed that her cancer is now in remission. Ecstatic, she shares ...
Meanwhile, Izzie Stevens (Katherine Heigl) misses her scheduled Interleukin 2 cancer treatment, leaving Alex Karev (Justin Chambers) distraught. Derek spends 10 hours in the OR analyzing the tumor, supported by Mark Sloan , Miranda Bailey (Chandra Wilson), and Callie Torres (Sara Ramirez). Despite Webber's orders to stop the surgery, Isaac ...
Katherine Heigl (Izzie Stevens) was absent from the episode due to her hiatus to film the romantic comedy Life as We Know It (2010). Upon its original broadcast, "I Saw What I Saw" was viewed by 15.40 million viewers in the United States, ranking #1 for the night, and garnered a 5.6/4 Nielsen rating/share in the 18–49 demographic. The episode ...