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a clear solution of blood plasma in the upper phase (which can be separated into its own fractions, see Blood plasma fractionation), the buffy coat, which is a thin layer of leukocytes (white blood cells) mixed with platelets in the middle, and; erythrocytes (red blood cells) at the bottom of the centrifuge tube.
The process of blood fractionation involves separation of blood into its main components. Blood fractionation refers generally to the process of separation using a centrifuge (centrifugation), after which three major blood components can be visualized: plasma, buffy coat and erythrocytes (blood cells). These separated components can be analyzed ...
Continuous flow centrifugation (CFC) historically required two venipunctures as "continuous" means the blood is collected, spun, and returned simultaneously. Newer systems can use a single venipuncture by pooling blood in a vessel and cycling through drawing and returning blood though the needle while the centrifuge continuously processes blood remaining in the vessel. [5]
The Cohn process, developed by Edwin J. Cohn, is a series of purification steps with the purpose of extracting albumin from blood plasma.The process is based on the differential solubility of albumin and other plasma proteins based on pH, ethanol concentration, temperature, ionic strength, and protein concentration.
In erythrocytapheresis, centrifugation is the most commonly used red blood cell fractionation method. This is because the hematocrit, or the percentage of blood volume taken up by red blood cells, is present in the highest percentage of all blood cell components in the solid portion of blood. Therefore, since erythrocytes have the highest ...
In whole blood, red blood cells, white blood cells, and platelets are suspended within the plasma. The goal of plasma purification and processing is to extract specific materials that are present in blood, and use them for restoration and repair. There are several components that make up blood plasma, one of which is the protein albumin ...
When patient blood is outside of the body passing through the plasmapheresis machine, the blood has a tendency to clot. To reduce this tendency, in one common protocol, [which?] sodium citrate is infused while the blood is running through the circuit. Citrate binds to calcium in the blood, calcium being essential for blood to clot. Citrate is ...