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The uncertainty and variability in the dose–response relationship of dioxins in terms of their toxicity, as well as the ability of dioxins to bioaccumulate, have led WHO experts to recommending very low tolerable daily intake (TDI) of dioxin, 1-4 pg/kg body weight per day, i.e. 7x10 −11 to 2.8x10 −10 g per 70-kg person per day, to allow ...
[2] [3] For general population the most important source is food of animal origin like with other dioxin-like compounds. [ 4 ] [ 5 ] [ 6 ] The most relevant congener is 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PCDF) which is more toxic and based on relative toxicity more prevalent than other PCDFs.
Coplanar PCBs are similar to dioxins and furans, both bind to the aryl hydrocarbon receptor (AhR) in organisms and may exert dioxin-like effects, in addition to the effects shared with non-coplanar PCBs. [9] [10] The AhR is a transcription factor, therefore, abnormal activation may disrupt cellular function by altering gene transcription. [9] [10]
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the reference chemical to which the toxicity of other dioxins and DLCs are compared. TCDD is the most toxic DLC known. Other dioxins and DLCs are assigned a scaling factor, or TEF, in comparison to TCDD. TCDD has a TEF of 1.0. Sometimes PCB 126 is also used as a reference chemical, with a TEF of 0.1.
The resulting combustion produced a highly toxic mixture of PCBs, dioxins and furans, which was included in the feed produced and subsequently fed to a large number of pigs. [ 88 ] According to data in 2009, [ 89 ] in 2005 the production of dioxin by the steel industry ILVA in Taranto ( Italy ) accounted for 90.3 per cent of the overall Italian ...
Management with a combination of abstinence from alcohol and the use of neuroleptics has been shown to be effective. [11] It is also possible to treat withdrawal before major symptoms start to happen in the body. Diazepam and chlordiazepoxide have proven to be effective in treating alcohol withdrawal symptoms such as alcoholic hallucinosis ...
Alcohol withdrawal syndrome (AWS) is a set of symptoms that can occur following a reduction in or cessation of alcohol use after a period of excessive use. [1] Symptoms typically include anxiety , shakiness , sweating, vomiting, fast heart rate , and a mild fever. [ 1 ]
Chemical compounds containing such rings are also referred to as furans. Furan is a colorless, flammable, highly volatile liquid with a boiling point close to room temperature. It is soluble in common organic solvents, including alcohol, ether, and acetone, and is slightly soluble in water. [2] Its odor is "strong, ethereal; chloroform-like". [3]
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