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THJ-2201 is an indazole-based synthetic cannabinoid that presumably acts as a potent agonist of the CB 1 receptor and has been sold online as a designer drug. [1] [2 ...
Compared to THC, which is a partial agonist at CB 1 receptors, JWH-018, and many synthetic cannabinoids, are full agonists. JWH-018 may cause intense anxiety, agitation, and in rare cases, has been assumed to have been the cause of seizures and convulsions. JWH-018 and analogs of it may present serious dangers to the user when used to excess. [22]
5F-CUMYL-PINACA (also known as SGT-25 and sometimes sold in e-cigarette form as C-Liquid) [1] is an indazole-3-carboxamide based synthetic cannabinoid. [2] 5F-CUMYL-PINACA acts as a potent agonist for the cannabinoid receptors, with the original patent claiming approximately 4x selectivity for CB 1, having an EC 50 of <0.1 nM for human CB 1 receptors and 0.37 nM for human CB 2 receptors. [3]
AMB-FUBINACA (also known as FUB-AMB and MMB-FUBINACA [3]) is an indazole-based synthetic cannabinoid that is a potent agonist for the cannabinoid receptors, with K i values of 10.04 nM at CB 1 and 0.786 nM at CB 2 and EC 50 values of 0.5433 nM at CB 1 and 0.1278 nM at CB 2, [4] and has been sold online as a designer drug.
XLR-11 (5"-fluoro-UR-144 or 5F-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB 1 and CB 2 with EC 50 values of 98 nM and 83 nM ...
AM-2201 is a full agonist for cannabinoid receptors. Affinities are: with a K i of 1.0 nM at CB 1 and 2.6 nM at CB 2. [6] The 4-methyl functional analog MAM-2201 probably has similar affinities. [original research?] AM-2201 has an EC 50 of 38 nM for human CB 1 receptors, and 58 nM for human CB 2 receptors. [7]
Onternabez (also known as HU-308, HU308, PPP-003, and ARDS-003) is a synthetic cannabinoid that acts as a potent cannabinoid agonist.It is highly selective for the cannabinoid-2 receptor (CB 2 receptor) subtype, with a selectivity more than 5,000 times greater for the CB 2 receptor than the CB 1 receptor.
AB-CHMINACA is an indazole-based synthetic cannabinoid.It is a potent agonist of the CB 1 receptor (K i = 0.78 nM) and CB 2 receptor (K i = 0.45 nM) and fully substitutes for Δ 9-THC in rat discrimination studies, while being 16x more potent.