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Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa).
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
After a short-term treatment with the mTOR inhibitors dactolisib and everolimus, in elderly (65 and older), treated subjects had a reduced number of infections over the course of a year. [ 166 ] Various natural compounds, including epigallocatechin gallate (EGCG), caffeine , curcumin , berberine , quercetin , resveratrol and pterostilbene ...
While most patients take GLP-1 drugs with few or no serious side effects, it's common to experience at least mild gastrointestinal issues like nausea, vomiting, stomach pain, constipation, and ...
Acute inflammation, like the redness and swelling that occurs with an injury, is a sign that your body is working properly—but chronic inflammation (long-term inflammation that lasts for months ...
Related: The One Thing You Should Never, Ever Do if You're Over 60 and Want To Stay Healthy. Daily exercise. Exercising regularly helps improve strength, muscle development and overall long-term ...
Many patients will not develop these side effects, although there is still a significant possibility of risks associated with Antipsychotic usage. The percentage of patients affected by side effects like Tardive dyskinesia is significantly high and estimated to be a 20-50% prevalence. [1] [2]
Intensive blood pressure control for adults with hypertension and high cardiovascular risk can reduce the risk of mild cognitive impairment or dementia in the long term, according to a new study ...