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Vitamin B 1 analogues are analogues of vitamin B 1, thiamine. They typically have improved bioavailability relative to thiamine itself, and are used to treat conditions caused by vitamin B 1 deficiency. These conditions include beriberi, Korsakoff's syndrome, Wernicke's encephalopathy and diabetic neuropathy.
Thiamine, also known as thiamin and vitamin B 1, is a vitamin – an essential micronutrient for humans and animals. [1] [3] [4] It is found in food and commercially synthesized to be a dietary supplement or medication. [1] Phosphorylated forms of thiamine are required for some metabolic reactions, including the breakdown of glucose and amino ...
Because thiamine deficiency causes problems with memory and other cognitive functions, thiamine and analogs like sulbutiamine have been studied in clinical trials in the 1980s and 1990s for age-associated cognitive decline. [10] Sulbutiamine has been explored in clinical trials as a potential treatment for chronic fatigue syndrome (CFS). [6]
Most multivitamins come in capsule form; tablets, powders, liquids, and injectable formulations also exist. In the United States, the FDA requires any product marketed as a "multivitamin" to contain at least three vitamins and minerals; furthermore, the dosages must be below a "tolerable upper limit", and a multivitamin may not include herbs ...
Fursultiamine (INN; chemical name thiamine tetrahydrofurfuryl disulfide or TTFD; brand names Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor, Lipothiamine) is a medication and vitamin used to treat thiamine deficiency. Chemically, it is a disulfide derivative of thiamine and is similar in structure to allithiamine. [1]
Prosultiamine (INN; also known as thiamine propyl disulfide or TPD; brand name Jubedel,) is a disulfide thiamine derivative discovered in garlic in Japan in the 1950s, and is similar to allithiamine. It was developed as a treatment for vitamin B 1 deficiency .
Since thiamine (vitamin B 1) is a very important substance required for metabolic pathways by almost all organisms, it can be very detrimental to introduce Thiaminase to a system. Frequently an organism gains this enzyme by ingesting another organism that carries it.
Well-researched human vitamin deficiencies involve thiamine (beriberi), niacin , [32] vitamin C (scurvy), folate (neural tube defects) and vitamin D (rickets). [8] In much of the developed world these deficiencies are rare due to an adequate supply of food and the addition of vitamins to common foods. [ 20 ]