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The first clinical manifestation of Paget's disease is usually an elevated alkaline phosphatase in the blood. [7] Paget's disease of right pelvic bone. Man of 80 years age. Paget's disease may be diagnosed using one or more of the following tests: Pagetic bone has a characteristic appearance on X-rays. A skeletal survey is therefore indicated.
Paget’s disease of bone is a chronic disorder characterized by abnormal bone remodeling. The pelvic brim sign arises due to excessive bone resorption due to increased osteoclastic activity in the early stages of the disease leads to localized bone loss, as well as excessive bone formation during the later stages of the diseases.
Other causes of bone diseases include severe impacts/injuries and weakness in bones/bone loss. The effects of bone disorders will vary with disease. The effects can occur physically, mentally and financially as well as impact the individuals quality of life. Orthopaedic disorders can drastically affect an individual's functional ability.
The hormone produced by the thyroid gland has big impact on bone density, blood calcium levee. [4] Abnormalities of the thyroid gland impact bone disease such as osteoporosis, a condition that is common in women but men can be diagnosed with this silent disease as well as it mainly affects elderly individual. [citation needed]
Multisystem proteinopathy (MSP) is a dominantly inherited, pleiotropic, degenerative disorder of humans that can affect muscle, bone, and/or the central nervous system.MSP can manifest clinically as classical amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), inclusion body myopathy (IBM), Paget's disease of bone (PDB), or as a combination of these disorders. [1]
Blade of grass sign (also known as flame sign [1]) is a radiologic sign referring to the lytic fronts seen in the leading edge of the long bone in Paget's disease. [2] It is usually seen as a wedge shaped area of radiolucency in the diaphysis of long bone. [1]
Platybasia is a spinal disease of a malformed relationship between the occipital bone and cervical spine. It may be caused by Paget's disease. Platybasia is also a feature of Gorlin-Goltz syndrome, commonly known as basal cell nevus syndrome. It may be developmental in origin or due to softening of the skull base bone, allowing it to be pushed ...
It is seen in multiple conditions and has been classically described for lepromatous leprosy as well as Paget's disease of bone. It is a dermatological symptom, with characteristic facial features that are visible on presentation, and is useful for focusing on differential diagnosis .