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Metformin has acid dissociation constant values (pK a) of 2.8 and 11.5, so it exists very largely as the hydrophilic cationic species at physiological pH values. The metformin pK a values make it a stronger base than most other basic medications with less than 0.01% nonionized in blood.
An amphoteric substance is one that can act as an acid or as a base, depending on pH. Water (below) is amphoteric. Water (below) is amphoteric. Another example of an amphoteric molecule is the bicarbonate ion HCO − 3 that is the conjugate base of the carbonic acid molecule H2CO3 in the equilibrium
A single unit of alcohol is defined as 10 ml. The number of units present in a typical drink is sometimes printed on bottles. The system is intended as an aid to people who are regulating the amount of alcohol they drink; it is not used to determine serving sizes. In the United States, the standard drink contains 0.6 US fluid ounces (18 ml) of ...
So, for example, the best time to take metformin 500mg once a day would be after your dinner. Depending on which type of metformin you take and your dose, however, you may take metformin more than ...
One litre (1000 ml) of typical Oktoberfest beer (5.5–6%) contains 5.5–6 UK units of alcohol. A beer bottle is typically between 333 and 355 ml (11.3 and 12.0 US fl oz), approximately 1.7 UK units at 5%. 375 ml (12.7 US fl oz) can of light beer (2.7% alcohol) = 0.8 Australian standard drinks
Another small study on people without diabetes who were overweight or had obesity found that those taking metformin lost between 5.6 and 6.5 percent of their body weight. In contrast, the control ...
Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to describing how the body affects a specific substance after administration. [1]
The Henderson–Hasselbalch equation can be used to model these equilibria. It is important to maintain this pH of 7.4 to ensure enzymes are able to work optimally. [10] Life threatening Acidosis (a low blood pH resulting in nausea, headaches, and even coma, and convulsions) is due to a lack of functioning of enzymes at a low pH. [10]