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Conditional gene knockout is a technique used to eliminate a specific gene in a certain tissue, such as the liver. [ 1 ][ 2 ] This technique is useful to study the role of individual genes in living organisms. It differs from traditional gene knockout because it targets specific genes at specific times rather than being deleted from beginning ...
Conditional mutation is a mutation that has wild-type (or less severe) phenotype under certain "permissive" environmental conditions and a mutant phenotype under certain "restrictive" conditions. For example, a temperature-sensitive mutation can cause cell death at high temperature (restrictive condition), but might have no deleterious ...
A genetic screen or mutagenesis screen is an experimental technique used to identify and select individuals who possess a phenotype of interest in a mutagenized population. [ 1 ] Hence a genetic screen is a type of phenotypic screen. Genetic screens can provide important information on gene function as well as the molecular events that underlie ...
The Mutations is a loose amalgam of Frankenstein and Freaks in which vapid technical jargon and cute time-lapse photography serve as a substitute for cinematic substance. The film, which takes as its subject biological innovation and rapid structural change, has been directed in such a tired, conventional manner that its form appears to be a ...
Lethal allele. Lethal alleles (also referred to as lethal or lethals) are alleles that cause the death of the organism that carries them. They are usually a result of mutations in genes that are essential for growth or development. [ 1 ] Lethal alleles may be recessive, dominant, or conditional depending on the gene or genes involved.
Evolutionary biologists have used mutation accumulation experiments, in which mutations are allowed to drift to fixation in inbred lines, to study the effect of spontaneous mutations on phenotype character. Phenotypic assays significantly determine whether and how quickly population with accumulated deleterious mutational loads can result in ...
Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. [ 6 ] Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) [ 7 ] have been identified in most mammals for which ...
Synthetic lethality is defined as a type of genetic interaction where the combination of two genetic events results in cell death or death of an organism. [1] Although the foregoing explanation is wider than this, it is common when referring to synthetic lethality to mean the situation arising by virtue of a combination of deficiencies of two or more genes leading to cell death (whether by ...