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  2. Human iron metabolism - Wikipedia

    en.wikipedia.org/wiki/Human_iron_metabolism

    Although this mechanism is an elegant response to short-term bacterial infection, it can cause problems when it goes on so long that the body is deprived of needed iron for red cell production. Inflammatory cytokines stimulate the liver to produce the iron metabolism regulator protein hepcidin , that reduces available iron.

  3. Haematopoietic system - Wikipedia

    en.wikipedia.org/wiki/Haematopoietic_system

    Red blood cells, also called erythrocytes, are the oxygen-carrying cells. Erythrocytes are functional and are released into the blood. The number of reticulocytes, immature red blood cells, gives an estimate of the rate of erythropoiesis. Lymphocytes are the cornerstone of the adaptive immune system. They are derived from common lymphoid ...

  4. Host response to cancer therapy - Wikipedia

    en.wikipedia.org/wiki/Host_response_to_cancer...

    The host response to cancer therapy is defined as a physiological response of the non-malignant cells of the body (also known as host cells) to a specific cancer therapy. The response is therapy-specific, occurring independently of cancer type or stage.

  5. Stimulator of interferon genes - Wikipedia

    en.wikipedia.org/wiki/Stimulator_of_interferon_genes

    [21] [22] Perforation of the phagosome membrane mediated by ESX1 secretion system allows extracellular mycobacterial DNA to access host cytosolic DNA sensors, thus inducing the production of type I interferon in macrophages. High type I interferon signature leads to the M. tuberculosis pathogenesis and prolonged infection. [22]

  6. Ferrochrome - Wikipedia

    en.wikipedia.org/wiki/Ferrochrome

    Ferrochrome or ferrochromium (FeCr) is a type of ferroalloy, that is, an alloy of chromium and iron, generally containing 50 to 70% chromium by weight. [ 1 ] [ 2 ] Ferrochrome is produced by electric arc carbothermic reduction of chromite .

  7. Inflammasome - Wikipedia

    en.wikipedia.org/wiki/Inflammasome

    The inflammasome was discovered by the team of Jürg Tschopp, at the University of Lausanne, in 2002. [17] [18] In 2002, it was first reported by Martinon et al. [17] that NLRP1 (NLR family PYD-containing 1) could assemble and oligomerize into a structure in vitro, which activated the caspase-1 cascade, thereby leading to the production of pro-inflammatory cytokines, including IL-1β and IL-18.

  8. Inflammatory cytokine - Wikipedia

    en.wikipedia.org/wiki/Inflammatory_cytokine

    Inflammatory cytokines play a role in initiating the inflammatory response and to regulate the host defence against pathogens mediating the innate immune response. [4] Some inflammatory cytokines have additional roles such as acting as growth factors. [5] Pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α also trigger pathological pain ...

  9. Immune response - Wikipedia

    en.wikipedia.org/wiki/Immune_response

    An immune response is a physiological reaction which occurs within an organism in the context of inflammation for the purpose of defending against exogenous factors. These include a wide variety of different toxins, viruses, intra- and extracellular bacteria, protozoa, helminths, and fungi which could cause serious problems to the health of the host organism if not cleared from the body.