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Producing adherent cells that create proteins of interest used for vaccine development. [10] Adherent cells used in conjunction with viral vectors for cell and gene therapy. [11] Delivering micro and nanotechnology to adherent cells in vitro. [12] Adjusting adherent cell morphology for cancer cell screening. [13]
Cells with short spiny neurite-like processes migrate out from these adherent clumps. SH-SY5Y cells possess an abnormal chromosome 1, where there is an additional copy of a 1q segment and is referred to trisomy 1q. SH-SY5Y cells are known to be dopamine beta hydroxylase active, acetylcholinergic, glutamatergic and adenosinergic. The cells have ...
Schematic of cell adhesion. Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indirect interaction, where cells attach to surrounding extracellular matrix, a gel-like structure containing molecules released ...
The International Society for Cellular Therapy (ISCT) has proposed a set of standards to define MSCs. A cell can be classified as an MSC if it shows plastic adherent properties under normal culture conditions and has a fibroblast-like morphology. In fact, some argue that MSCs and fibroblasts are functionally identical. [15]
During mitosis, cells undergo changes in morphology, and mitotic selection takes advantage of this in adherent cells grown in a monolayer. The cells become more spherical, decreasing the surface area of cell membrane attached to the culture plate. Mitotic cells can therefore be completely detached by gently shaking and collected from the ...
The cells have a round, epithelial morphology, and are adherent in cell culture. MIA PaCa-2 has served for decades as a model of pancreatic cancer, and studies of MIA PaCa-2 physiology have helped clarify the mechanisms of carcinogenesis in pancreatic cancer, [ 1 ] aid the development of cancer cell lysates targeting IgG production, [ 3 ] and ...
Adherent cells require a surface, such as tissue culture plastic or microcarrier, which may be coated with extracellular matrix (such as collagen and laminin) components to increase adhesion properties and provide other signals needed for growth and differentiation. Most cells derived from solid tissues are adherent.
Trypsinization is the process of cell dissociation using trypsin, a proteolytic enzyme which breaks down proteins, to dissociate adherent cells from the vessel in which they are being cultured. When added to cell culture, trypsin breaks down the proteins that enable the cells to adhere to the vessel.