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Oxygenation zones are numbered inside the diamond-shaped acinus (in red). Zone three is closest to the central vein and zone one is closest to the portal triad. Zones differ by function: zone I hepatocytes are specialized for oxidative liver functions such as gluconeogenesis, β-oxidation of fatty acids and cholesterol synthesis
A large amount of reactive oxygen species, pro-inflammatory cytokines and chemokines are produced by the activated Kupffer cells which lead to liver injury. The cascade begins with endotoxin-mediated activation of the Toll-like receptor 4 ( TLR4 ) and CD14 , receptors on the Kupffer cell that internalize endotoxin.
A liver sinusoid is a type of capillary known as a sinusoidal capillary, discontinuous capillary or sinusoid, that is similar to a fenestrated capillary, having discontinuous endothelium that serves as a location for mixing of the oxygen-rich blood from the hepatic artery and the nutrient-rich blood from the portal vein.
In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs [1] that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation. [2] [3] They are located on the left and right in the retroperitoneal space, and in adult humans are about 12 centimetres (4 + 1 ⁄ 2 inches) in length.
The gallbladder is located on the undersurface of the right lobe of the liver. [9] It produces bile, which is used to help process fats in the body. [9] Humans can live without the gallbladder. [10] The largest lymphatic organ is the spleen, which is dark purple and located under the lower ribs, around the left side of the upper abdomen.
One of these the lesser sac is located behind the stomach and joins into the greater sac via the foramen of Winslow. [1] Some of the organs are attached to the walls of the abdomen via folds of peritoneum and ligaments, such as the liver and others use broad areas of the peritoneum, such as the pancreas.
The falciform ligament, visible on the front of the liver, makes a superficial division of the right and left lobes of the liver. From the underside, the two additional lobes are located on the right lobe. [2] A line can be imagined running from the left of the vena cava and all the way forward to divide the liver and gallbladder into two ...
A liver segment is one of eight segments of the liver as described in the widely used Couinaud classification (named after Claude Couinaud) in the anatomy of the liver.This system divides the lobes of the liver into eight segments based on a transverse plane through the bifurcation of the main portal vein, [1] arranged in a clockwise manner starting from the caudate lobe.
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