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Human B1 cells have been found to have marker profile of CD20+CD27+CD43+CD70- and could either be CD5+ or CD5-, which has been debated since. [3] CD5-CD72 is thought to mediate B cell-B cell interaction. What differentiates B1 cells from other B cells is the variable existence of CD5, CD86, IgM and IgD. [1]
The MZ B cells within this region typically express low-affinity polyreactive B-cell receptors (BCR), high levels of IgM, Toll-like receptors (TLRs), CD21, CD1, CD9, CD27 with low to negligible levels of secreted-IgD, CD23, CD5, and CD11b that help to distinguish them phenotypically from follicular (FO) B cells and B1 B cells. [2] [3]
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. [1] They function in the humoral immunity component of the adaptive immune system. [1] B cells produce antibody molecules which may be either secreted or inserted into the plasma membrane where they serve as a part of B-cell receptors. [2]
T-independent memory B cells are a subset called B1 cells. These cells generally reside in the peritoneal cavity. When reintroduced to antigen, some of these B1 cells can differentiate into memory B cells without interacting with a T cell. [4] These B cells produce IgM antibodies to help clear infection. [20] T-bet memory B cells
Regulatory B cells (Bregs or B reg cells) represent a small population of B cells that participates in immunomodulation and in the suppression of immune responses. The population of Bregs can be further separated into different human or murine subsets such as B10 cells, marginal zone B cells, Br1 cells, GrB + B cells, CD9 + B cells, and even some plasmablasts or plasma cells.
1 B1 cell group. 2 B2 cell group. 3 B3 cell group. 4 B4 cell group. 5 B5 cell group. 6 B6 cell group. 7 B7 cell group. 8 B8 cell group. 9 B9 cell group. 10 References ...
69816 Ensembl ENSG00000170476 ENSMUSG00000024353 UniProt Q8WU39 Q9D8I1 RefSeq (mRNA) NM_016459 NM_027222 RefSeq (protein) NP_057543 NP_081498 Location (UCSC) Chr 5: 139.39 – 139.39 Mb Chr 18: 35.78 – 35.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Marginal zone B and B1 cell-specific protein is a protein that in humans is encoded by the MZB1 gene. References ^ a b c GRCh38 ...
FO B cells express high levels of IgD, and CD23; lower levels of CD21 and IgM; and no CD1 or CD5, readily distinguishing this compartment from B1 B cells and marginal zone B-cells. FO B cells organize into the primary follicles of B cell zones focused around follicular dendritic cells in the white pulp of the spleen and the cortical areas of ...
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