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Beyond adverse effects from the herb itself, "adulteration, inappropriate formulation, or lack of understanding of plant and drug interactions have led to adverse reactions that are sometimes life threatening or lethal." [3]
Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]
When used in combination with an anticoagulant or anti-platelet drug, saw palmetto extract can increase the risk of bleeding by enhancing the anticoagulation or anti-platelet effects. [3] Some examples of anticoagulant and anti-platelet drugs include aspirin, clopidogrel, nonsteroidal anti-inflammatory drugs (NSAIDs), and warfarin. [3]
If you’ve ever seen a drug commercial, you know every medication or supplement has some side effects — and saw palmetto is no exception there (though the side effects are generally mild).
The first hydrogen bond is a strong interaction which comes from the carbonyl oxygen of the oxazolidinone core of rivaroxaban. The second hydrogen bond is a weaker interaction and comes from the amino group of the clorothiophene carboxamide moiety. These two hydrogen bonds result in the drug forming an L-shape and fits in the S1 and S4 pockets.
How saw palmetto extract may help benefit men by reducing the uncomfortable symptoms of an enlarged prostate, including not being able to urinate easily.
For those not aware of the magical ingredient, saw palmetto is a small palm that contains fruit which, when extracted for its nutrients, has been shown to inhibit the production of DHT, a hormon ...
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds ...