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Symptoms begin some six days after exposure (between 4 and 28 days, with the average being 16 to 17 days [29]) and last about a week. The rash that children experience will appear after few days after the initial symptoms and can spread all over the body. [28]
Out of these, 20% of the females may experience continuous joint stiffness for several months or years. Symptoms can persist up to 3 weeks since onset. [15] Sometimes, fifth disease can also cause serious complications, especially if the person is pregnant, has anemia, or is immunocompromised; affecting the blood system, joints or nerves. [13]
Human bocavirus 1 is a common cause of acute respiratory tract infection, especially in young children, wheezing being a common symptom. Other parvoviruses associated with different diseases in humans include human parvovirus 4 and human bufavirus, though the manner by which these viruses cause disease is unclear.
Hand, foot, and mouth disease (HFMD) is a common infection caused by a group of enteroviruses. [10] It typically begins with a fever and feeling generally unwell. [10] This is followed a day or two later by flat discolored spots or bumps that may blister, on the hands, feet and mouth and occasionally buttocks and groin.
Individuals with TEC have a median age of presentation of 18–26 months; however, the disorder may occur in infants younger than 6 months and in children as old as age 10 years. Because of the gradual onset of the anemia, children are often healthier than expected from their low hemoglobin levels.
They often fade by three to six weeks after birth, leaving brownish marks. [3] When due to a cancer, the bumps tend to be fewer, firmer and larger. [2] The condition can occur following infection of an unborn baby with rubella, cytomegalovirus, toxoplasmosis, or coxsackie virus. [4] Other viral causes include parvovirus B19 and herpes simplex. [1]
A diagnosis can be made from clinical signs and symptoms, and treatment consists of minimizing the discomfort of symptoms. [5] It can be differentiated from herpetic gingivostomatitis by the positioning of vesicles - in herpangina, they are typically found on the posterior oropharynx, as compared to gingivostomatitis where they are typically found on the anterior oropharynx and the mouth.
Despite strong circumstantial evidence, [80] a direct causal role of PPV-contaminated semen in reproductive failure has not been established unequivocally. [82] The zona pellucida could protect the early embryo while local immunity is developing. Conversely, the virus may cause uterine changes incompatible with gestation. [94]