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The enzyme phospholipase A 2 (EC 3.1.1.4, PLA 2, systematic name phosphatidylcholine 2-acylhydrolase) catalyses the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycerol molecule:
A phospholipase is an enzyme that hydrolyzes phospholipids [1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C, and D, which are distinguished by the type of reaction which they catalyze: Phospholipase A Phospholipase A 1 – cleaves the sn-1 acyl chain (where sn refers to stereospecific numbering).
Lipoprotein-associated phospholipase A 2 (Lp-PLA 2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A 2 enzyme that in humans is encoded by the PLA2G7 gene. [5] [6] Lp-PLA 2 is a 45-kDa protein of 441 amino acids. [7] It is one of several PAF acetylhydrolases.
18786 Ensembl ENSG00000137055 ENSMUSG00000028577 UniProt Q9Y263 P27612 RefSeq (mRNA) NM_001031689 NM_004253 NM_001321546 NM_172695 RefSeq (protein) NP_001026859 NP_001308475 NP_766283 Location (UCSC) Chr 9: 26.9 – 26.95 Mb Chr 4: 94.46 – 94.49 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phospholipase A-2-activating protein is an enzyme that in humans is encoded by the PLAA ...
LYPLA3, also known as Group XV phospholipase A2, is an enzyme that in humans is encoded by the PLA2G15 gene. [5] [6] [7] Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free ...
78390 Ensembl ENSG00000159337 ENSMUSG00000070719 UniProt Q86XP0 Q50L43 RefSeq (mRNA) NM_178034 NM_001024137 RefSeq (protein) NP_828848 NP_001019308 Location (UCSC) Chr 15: 42.07 – 42.09 Mb Chr 2: 120.1 – 120.12 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phospholipase A2 group IVD is a protein that in humans is encoded by the PLA2G4D gene. Function The phospholipase A2 enzyme ...
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85 kDa calcium-independent phospholipase A2, also known as 85/88 kDa calcium-independent phospholipase A2, Group VI phospholipase A2, Intracellular membrane-associated calcium-independent phospholipase A2 beta, or Patatin-like phospholipase domain-containing protein 9 is an enzyme that in humans is encoded by the PLA2G6 gene.