Search results
Results from the WOW.Com Content Network
An apple type reaction a chemoselective reduction of the aldehyde formed is used to form 2. Knochel’s protocol is used to provoke sp3-sp3 coupling with tert-butyl-2-(bromomethyl)acrylate after which the compound is used as a substrate in a ring closing metathesis reaction under influence of a Grubbs II catalyst.
Butyl acrylate is of low acute toxicity with an LD 50 (rat) of 3143 mg/kg. [4]In rodent models, butyl acrylate is metabolized by carboxylesterase or reactions with glutathione; this detoxification produces acrylic acid, butanol, and mercapturic acid waste, which are excreted.
Acrylates (IUPAC: prop-2-enoates) are the salts, esters, and conjugate bases of acrylic acid. The acrylate ion is the anion CH 2 =CHCO − 2. Often, acrylate refers to esters of acrylic acid, the most common member being methyl acrylate. These acrylates contain vinyl groups.
tert-Butyl methacrylate is an organic compound with the formula (CH 3) 3 CO 2 CC(CH 3)=CH 2. A colorless solid, it is a common monomer for the preparation of meth acrylate polymers . [ 2 ] It is employed in other kinds of polymerizations .
Base catalysed Michael addition of methyl acrylate to 2,6-di-tert-butylphenol forms the intermediate butyl-phloretic ester. High temperature transesterification of this with pentaerythritol gives the final product. Driving this reaction to completion can be difficult and commercial samples often contain low levels of the tri-ester.
tert-Butyl bromide (also referred to as 2-bromo-2-methylpropane) is an organic compound with the formula Me 3 CBr (Me = methyl). The molecule features a tert-butyl group attached to a bromide substituent. This organobromine compound is used as a standard reagent in synthetic organic chemistry. It is a colorless liquid.
The standard industrial reaction for producing methyl acrylate is esterification of acrylic acid with methanol under acid catalysis (sulfuric acid, p-toluenesulfonic acid or acidic ion exchangers. [7]). The transesterification is facilitated because methanol and methyl acrylate form a low boiling azeotrope (boiling point 62–63 °C). [8]
tert-Butyloxycarbonyl protecting group. The tert-butyloxycarbonyl protecting group or tert-butoxycarbonyl protecting group [1] (BOC group) is an acid-labile protecting group used in organic synthesis. The BOC group can be added to amines under aqueous conditions using di-tert-butyl dicarbonate in the presence of a base such as sodium hydroxide: