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The two main types of anti-resorptive drugs are bisphosphonate and denosumab. These drugs help to decrease the risk of bone fracture and bone pain. Because the mandible has a faster remodeling rate compared to other bones in the body, it is more affected by the effects of these drugs. [30] Bisphosphonate
Adverse effects of this approach also include pain, nerve damage, and loss of sensation due to the location of the inferior alveolar nerve. Anti-inflammatory medication can be used to slow the resorption process. Arthrocentesis, and arthroscopic surgery are also sometimes used to treat disc displacement and other symptoms. [2]
The pain is more usually unilateral (located on one side) rather than bilateral. [20] It is rarely severe. [25] Limited range of mandibular movement, [2] which may cause difficulty eating or even talking. There may be locking of the jaw, or stiffness in the jaw muscles and the joints, especially present upon waking. [19]
Patients taking dexamethasone and other glucocorticoids are at increased risk. [22] Matrix metalloproteinase 2 may be a candidate gene for bisphosphonate-associated osteonecrosis of the jaw, since it is the only gene known to be associated with bone abnormalities and atrial fibrillation, both of which are side effects of bisphosphonates. [23]
Eagle syndrome (also termed stylohyoid syndrome, [1] styloid syndrome, [2] stylalgia, [3] styloid-stylohyoid syndrome, [2] or styloid–carotid artery syndrome) [4] is an uncommon condition commonly characterized but not limited to sudden, sharp nerve-like pain in the jaw bone and joint, back of the throat, and base of the tongue, triggered by swallowing, moving the jaw, or turning the neck. [1]
Phossy jaw, formally known as phosphorus necrosis of the jaw, was an occupational disease affecting those who worked with white phosphorus (also known as yellow phosphorus) without proper safeguards. It is also likely to occur as the result of use of chemical weapons that contain white phosphorus.
In 2017, Dr. Jared Jagdeo, a dermatologist who was a consultant for Zeltiq at the time, co-authored a journal article suggesting PAH be considered a more common risk.
Today, however, the condition is often a hidden infection, due in part to not being visible on most dental X-rays unless there is a substantial loss of bone density. In addition, some schools of dentistry do not recognize "silent" OM of the jaws—occurrence of the condition without visually obvious manifestations—in their curriculum.
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