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Colloidal gold is a sol or colloidal suspension of nanoparticles of gold in a fluid, usually water. [1] The colloid is coloured usually either wine red (for spherical particles less than 100 nm) or blue-purple (for larger spherical particles or nanorods). [2]
In photothermal cancer therapy, many gold nanoparticle molecules are used in each test and they must all be uniform in size. Including PEG coating, the nanoparticles measured to be ~130 nm in diameter. [1] Gold nanoparticles that act as drug delivery systems in conjugation with chemotherapeutic drugs typically range in size from 10 to 100 nm. [2]
Gold nanoparticles have been used in the past for pharmaceutical and medical uses, but only recently have cosmetic brands sought patents for gold nanoparticles to use them for cosmetic formulation. Research conducted by Tatsiana Mironava, PhD, from Stony Brook University concluded that the size, concentration and frequency of application plays ...
Gold nanoparticles (such as AuNPs) have the benefit of being biocompatible and the flexibility to have multiple different molecules, and fundamental materials, attached to their shell (almost anything that can normally be attached to gold can be attached to the gold nano-shell, which can be used in helping identifying and treating cancer).
In another study, the effect of spherical gold nanoparticles as a wound healing agent was tested in rat model by coupling gold nanoparticles with photobiomodulation therapy (PBMT). PBMT is a light stimulated therapy that is used for wound healing treatment without any significant temperature changes. [ 21 ]
Whereas gold nanoparticles absorb light in the visible spectrum of light (at about 550 nm), gold nanocages absorb light in the near-infrared, [2] where biological tissues absorb the least light. Because they are also biocompatible, gold nanocages are promising as a contrast agent for optical coherence tomography.
Gold nanoparticles can be purchased or synthesized via a variety of methods. [12] Several strategies exist for functionalizing gold nanoparticles with single-stranded DNA; one of the most commonly utilized strategies involves introducing thiol-terminated DNA to a solution of gold nanoparticles and gradually increasing the concentration of a salt, like NaCl.
BINAP-functionalized palladium nanoparticles and gold nanoparticles have been used for the hydrosilylaytion of styrene under mild conditions; they were found to be more catalytically active and more stable than non-nanoparticle Pd-BINAP complexes. [11] [12] The reaction may also be catalyzed by a nanoparticle that consists of two metals. [5] [13]
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