Ads
related to: solid phase peptide synthesis resin or metal in water based- Discovery
We Generate Highly Constrained
Redox-Stable Peptides. Know More.
- Lead Optimization
Our Skilled Team Is Well-Equipped
With Many Years Of Experience.
- Instant Quote and Order
Order your custom peptide online.
Price match function available.
- Microbiology
Enzyme Substrates
chromogenic, fluorogenic indicators
- Discovery
creative-diagnostics.com has been visited by 10K+ users in the past month
Search results
Results from the WOW.Com Content Network
The solid phase now bears a dipeptide. This cycle is repeated to form the desired peptide chain. After all reactions are complete, the synthesised peptide is cleaved from the bead. The protecting groups for the amino groups mostly used in the peptide synthesis are 9-fluorenylmethyloxycarbonyl group and t-butyloxycarbonyl . A number of amino ...
The chemical synthesis of peptides can be carried out using classical solution-phase techniques, although these have been replaced in most research and development settings by solid-phase methods (see below). [3] Solution-phase synthesis retains its usefulness in large-scale production of peptides for industrial purposes moreover.
Within solid phase peptide synthesis (SPPS) there exist two strategies for the synthesis of glycopeptides, linear and convergent assembly. Linear assembly relies on the synthesis of building blocks and then the use of SPPS to attach the building block together. An outline of this approach is illustrated below. Scheme 1.
Merrifield Resin is a cross-linked polystyrene resin that carries a chloromethyl functional group. Merrifield resin is named after its inventor, Robert Bruce Merrifield (1984 winner of the Nobel Prize in Chemistry), and used in solid-phase synthesis. The material is typically available as white beads.
HBTU (Hexafluorophosphate Benzotriazole Tetramethyl Uronium) is a coupling reagent used in solid phase peptide synthesis. It was introduced in 1978 and shows resistance against racemization. [3] [4] It is used because of its mild activating properties. [5]
The original method is based on the solid-phase synthesis of Merrifield [5] The procedure is illustrated in the figure by the flowing diagram showing of a two-cycle synthesis using the same three BBs in both cycles. Choosing the solid phase method in the S&P synthesis is reasonable since otherwise removal of the by-products from the mixture of ...
Ads
related to: solid phase peptide synthesis resin or metal in water basedcreative-diagnostics.com has been visited by 10K+ users in the past month