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Alpha-gal syndrome (AGS), also known as alpha-gal allergy or mammalian meat allergy (MMA), [1] is a type of acquired allergy characterized by a delayed onset of symptoms (3–8 hours) after ingesting mammalian meat. The condition results from past exposure to certain tick bites and was first reported in 2002.
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The blood of cows, deer, goats and pigs contains a specific sugar molecule called alpha-gal. It is not found in humans, fish or birds. When ticks, usually the lone star tick, feed on those mammals ...
Alpha gal has also been suggested to play a role in an immunoglobulin E-specific allergic response to some meats. [4] While this allergic response is quite well documented, there is significant discrepancy between laboratory tests and clinical findings, indicating that much research must still be done on the alpha gal mechanism of action and ...
Mayo Clinic is a nonprofit hospital system with campuses in Rochester, Minnesota; Scottsdale and Phoenix, Arizona; and Jacksonville, Florida. [22] [23] Mayo Clinic employs 76,000 people, including more than 7,300 physicians and clinical residents and over 66,000 allied health staff, as of 2022. [5]
Alpha-gal may refer to: Alpha-galactosidase, an enzyme; Galactose-alpha-1,3-galactose, a carbohydrate also known as Galili antigen; Alpha-gal allergy
The lack of alpha-galactosidase leads to Fabry disease. A deficiency of alpha-galactosidase A (a-GAL A, encoded by GLA ) due to mutation causes a glycolipid known as globotriaosylceramide (abbreviated as Gb3, GL-3, or ceramide trihexoside) to accumulate within the blood vessels , other tissues, and organs. [ 11 ]
A new approach to a routine blood test could predict a person’s 30-year risk of heart disease, research published Saturday in the New England Journal of Medicine found.