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675 12190 Ensembl ENSG00000139618 ENSMUSG00000041147 UniProt P51587 P97929 RefSeq (mRNA) NM_000059 NM_001081001 NM_009765 RefSeq (protein) NP_000050 NP_001074470 NP_033895 Location (UCSC) Chr 13: 32.32 – 32.4 Mb Chr 5: 150.45 – 150.49 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse BRCA2 and BRCA2 are human genes and their protein products, respectively. The official symbol ...
Inheriting one BRCA1 mutation and one BRCA2 mutation has been reported occasionally; the child's risk for any given type of cancer is the higher risk of the two genes (e.g., the ovarian cancer risk from BRCA1 and the pancreatic cancer risk from BRCA2). Inheriting two BRCA2 mutations produces Fanconi anemia. [9]: 82–85
Optical mapping [1] is a technique for constructing ordered, genome-wide, high-resolution restriction maps from single, stained molecules of DNA, called "optical maps". By mapping the location of restriction enzyme sites along the unknown DNA of an organism, the spectrum of resulting DNA fragments collectively serves as a unique "fingerprint" or "barcode" for that sequence.
Mutations in genes responsible for HR are prevalent among human cancers. The BRCA1 and BRCA2 genes are centrally involved in HR, DNAdamage repair, end resection, and checkpoint signaling. Mutational signatures of HRD have been identified in over 20% of breast cancers, as well as pancreatic, ovarian, and gastric cancers.
There are two distinctive mapping approaches used in the field of genome mapping: genetic maps (also known as linkage maps) [7] and physical maps. [3] While both maps are a collection of genetic markers and gene loci, [8] genetic maps' distances are based on the genetic linkage information, while physical maps use actual physical distances usually measured in number of base pairs.
BRCA mutation, mutations in two genes which produce a hereditary breast-ovarian cancer syndrome BRCA1, the first of these genes to be discovered; BRCA2, the second of these genes to be discovered; British Radio Car Association, a British radio controlled car racing organisation; Brotherhood Railway Carmen of America, a defunct American trade union
66165 Ensembl ENSG00000107949 ENSMUSG00000030983 UniProt Q9P287 Q9CWI3 RefSeq (mRNA) NM_078469 NM_016567 NM_078468 NM_025392 RefSeq (protein) NP_057651 NP_510868 NP_510869 NP_079668 Location (UCSC) Chr 10: 125.82 – 125.85 Mb Chr 7: 133.31 – 133.32 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in ...
This gene encodes the protein for complementation group D2. This protein is monoubiquitinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins ( BRCA1 and BRCA2 ) involved in homology-directed DNA repair (see Figure: Recombinational repair of DNA double-strand damages).