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The repressor is shown in complex with operator DNA (gold) and ONPF (green), an anti-inducer ligand (i.e. a stabilizer of DNA binding) The lac repressor (LacI) is a DNA-binding protein that inhibits the expression of genes coding for proteins involved in the metabolism of lactose in bacteria. These genes are repressed when lactose is not ...
Benno Müller-Hill (5 February 1933 – 11 August 2018) [1] was a German biologist and author. Together with Walter Gilbert, Müller-Hill purified the lac repressor, the first genetic control protein to be isolated. [2] Müller-Hill has lectured widely and written books on the misuse of science by the Nazis. He was a professor of Genetics at ...
The lac operon in the prokaryote E. coli consists of genes that produce enzymes to break down lactose. Its operon is an example of a prokaryotic silencer. The three functional genes in this operon are lacZ, lacY, and lacA. [6] The repressor gene, lacI, will produce the repressor protein LacI which is under allosteric regulation.
Up-regulation is a process which occurs within a cell triggered by a signal (originating internal or external to the cell), which results in increased expression of one or more genes and as a result the proteins encoded by those genes. Conversely, down-regulation is a process resulting in decreased gene and corresponding protein expression.
Function. β-Galactosidase is an exoglycosidase which hydrolyzes the β- glycosidic bond formed between a galactose and its organic moiety. It may also cleave fucosides and arabinosides but at a much lower rate. It is an essential enzyme in the human body. Deficiencies in the protein can result in galactosialidosis or Morquio B syndrome.
Jacques Lucien Monod (French: [mÉ”no]; 9 February 1910 – 31 May 1976) was a French biochemist who won the Nobel Prize in Physiology or Medicine in 1965, sharing it with François Jacob and André Lwoff "for their discoveries concerning genetic control of enzyme and virus synthesis". [2][3][4][5][6][7] Monod and Jacob became famous for their ...
Repressilator. The repressilator is a genetic regulatory network consisting of at least one feedback loop with at least three genes, each expressing a protein that represses the next gene in the loop. [ 1] In biological research, repressilators have been used to build cellular models and understand cell function.
In addition, the transactivation and signal-sensing functions are frequently contained within the same domain. Domain architecture example: Lactose Repressor (LacI). The N-terminal DNA binding domain (labeled) of the lac repressor binds its target DNA sequence (gold) in the major groove using a helix-turn-helix motif. Effector molecule binding ...