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  2. Bisphosphonate - Wikipedia

    en.wikipedia.org/wiki/Bisphosphonate

    In large studies, women taking bisphosphonates for osteoporosis have had unusual fractures ("bisphosphonate fractures") in the femur (thigh bone) in the shaft (diaphysis or sub-trochanteric region) of the bone, rather than at the femoral neck, which is the most common site of fracture. However, these fractures are rare (12 in 14,195 women ...

  3. Discovery and development of bisphosphonates - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Nitrogen containing bisphosphonates are the current most used drugs in the class because of their potency. [15] Studies have showed that nitrogen on bisphosphonates forms hydrogen bond with threonine (Thr201) and the carbonyl part of Lysine (Lys200) on target enzyme, therefore enhancing the binding of the complex. Altering the position of ...

  4. Osteoporosis - Wikipedia

    en.wikipedia.org/wiki/Osteoporosis

    When on treatment with bisphosphonates rechecking bone mineral density is not needed. [174] There is tentative evidence of benefit in males with osteoporosis. [178] Fluoride supplementation does not appear to be effective in postmenopausal osteoporosis, as even though it increases bone density, it does not decrease the risk of fractures. [179 ...

  5. Phosphonate - Wikipedia

    en.wikipedia.org/wiki/Phosphonate

    Bisphosphonates are popular drugs for treatment of osteoporosis. [1] Clodronic acid is a bisphosphonate used as a drug to treat osteoporosis. In biochemistry and medicinal chemistry, phosphonate groups are used as stable bioisosteres for phosphate, such as in the antiviral nucleotide analog, Tenofovir, one of the cornerstones of anti-HIV therapy.

  6. Category:Bisphosphonates - Wikipedia

    en.wikipedia.org/wiki/Category:Bisphosphonates

    This page was last edited on 23 February 2016, at 09:15 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.

  7. Medication-related osteonecrosis of the jaw - Wikipedia

    en.wikipedia.org/wiki/Medication-related_osteo...

    There is no known prevention for bisphosphonate-associated osteonecrosis of the jaw. [6] Avoiding the use of bisphosphonates is not a viable preventive strategy on a general-population basis because the medications are beneficial in the treatment and prevention of osteoporosis (including prevention of bony fractures) and treatment of bone cancers.

  8. Etidronic acid - Wikipedia

    en.wikipedia.org/wiki/Etidronic_acid

    Etidronic acid is a bisphosphonate used to strengthen bone, treat osteoporosis, and treat Paget's disease of bone.. Bisphosphonates primarily reduce osteoclastic activity, which prevents bone resorption, and thus moves the bone resorption/formation equilibrium toward the formation side and hence makes bone stronger on the long run.

  9. Ibandronic acid - Wikipedia

    en.wikipedia.org/wiki/Ibandronic_acid

    Ibandronic acid is a bisphosphonate medication used in the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in people with cancer. [4] It may also be used to treat hypercalcemia (elevated blood calcium levels). It is typically formulated as its sodium salt ibandronate sodium. [medical citation needed]